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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b5d45298f2d1d6316d43c3e8a0d294dca420561003b2bbd7030730af1c16f004' 
  AND token = 'XN23A+uCZWpS+wlOT4lo1cmJUTRu1iSuf8q5lmMs+oY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}