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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6d648f8752aa9b8431cfc0044aaca51e27556b528c326b5aa3eb8eb8d7aa6d40' 
  AND token = 'TjNI1Cpc3UKzbtgNHxaql84v9qOv5qzT1ZG3+5XNvx0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}