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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f037271da49b711cba85eee03d778a65e0b8d8f1daec1669983f537be7c59b68' 
  AND token = 'kf9MCrcikD21099viCOE9B8LkYkgFe+TSemCswshac8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00054

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}