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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e0e3248c977449292473fa0c60a4c4c049c905fa285a3bbb4ded7cdd95505f71' 
  AND token = 'LMeYZ4imXsCeqZ2vXiLCW/i2LYxTrlxoQ0IFXmFxHt0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}