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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78812cc1c927f6f603c1e66f1e524b2565084d4224b2f120fb3d75f846ffaf6e' 
  AND token = 'uQ87pzr/YDUDFMPMnYD2C4dbn6uU6crJc6SYLPh8HtI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}