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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '434fef48b84fc7ca866d603bb156923a1196b5be1a05ec6d15820f33fea5b6d4' 
  AND token = 'HjPsmydcuDegtdqiVEBx+WXU0oYcZehNtPgVdn4Etdo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}