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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50dc28b68cdb9b60065aeb4bf49eef8eb26ebe8fd5d7a39d19019c3c236bb643' 
  AND token = 'mZgkidyILwyz8i9ptOKnEJIAC1bSO2IxEQVbH+FlMN4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}