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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '444f4b921db3b9d49ae684291d8c4a1eac9f9e8304ccedba748884caa4fc89d1' 
  AND token = '2plRwelfYQmdIkTrX+2CLLCTdxeARAtyfVAwmunv/18=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}