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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78164b069728b9bbc4aed8a8dd7e56ed4eaa733d8d265312645b03b79da02523' 
  AND token = '33oXVQ5bhlr8hYE1UFBg9aBybEOYm/cq2IVsfCMu9/4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}