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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd221300fcc5b3a8567b9f85e2e9b07c24cfe2e2e213553d57b329108aa522b81' 
  AND token = 'Q8Hh1vawT93+kUdoKSneT4FxuiVZIycJKJx2HV1+5yc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}