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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42c15ab4f2c3545f71060b10abbea6a04fd869e6c44ce8528a16b4501e660ee8' 
  AND token = 'CJSYsl42yBETYXSc7miCfwtE1wF/G+cFUiJM9SLH9DA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}