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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1b8c18e3e7f11d03fbd9159a41f72c386ba6157ade714b3479c83744cd590545' 
  AND token = 'GdpB4Vn0l6pZsvEEohkakcc7+2bIwJGXxRhxx6Um9Bo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}