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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '67344f3a978a9a9d6c83378774f33cf685962f8ad744aaad4b08753b7b2648c1' 
  AND token = 'bwS3yGYzeRH6ZdUpryash4XuYAvJWPY35BnRVCtGrJY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}