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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'dd05a63dcccce5642d04d3545e5b0d95c243d4e1147934e4dcd9b92b3eb79fea' 
  AND token = 'rJOQjJ/TdUxe/iyxJmXFuKLqYbtJ/aKdBOModqQ4JaY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}