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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21322b22bfba8957470e310eec7c170fc11c0b391520a84787be8059f5e7a4d0' 
  AND token = 'tyVNQTwr/VFs1D+xzjHxNMOR8YqxFYuaMIowWX2YE/I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00038

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}