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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80c6012bfe773f78b52d9954a020ac8a0b663eb25774cc7bbe225b7549c824a5' 
  AND token = 'WDe9o5ZxpdGWgvXYSrsz3q+whbSlwB2D0tT8Tdm6Efs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}