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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21051ff99d2c622b532e762b2ce6d18110d6907aa00416075db25b2043dbde86' 
  AND token = 'FzjNZfZzUaI/xKVw+zbiNOOQm5aVry+SScMJUh35obA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00054

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}