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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '889a6836ef31ba84253cad16d196eb3a572537999ca8ddf4ad89b7e74ebbc388' 
  AND token = 'TMJsZns+WZuQSCZfqTT9cF3B1otLasL/x/MvOpE+Qj8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}