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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65dea65054fcbfc5d89a56a598951a26e4fabede6b61d0da901985cfdaa521d5' 
  AND token = '190au5Hh6OBifDkoPFC58f81Zt1akL1Elxge/UXL9OE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}