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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '11415539d09fda18a4799010b002eac39c25c44821bdbc002c498d0b22f32a37' 
  AND token = '5E7pJgsbTHzz1gTUtA2ATEGD/mJEpoSLtyQEP9l6hOE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}