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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78be7a79d72a9a7c328846495ada8dcaea172351b3c0fcacacc1b0cb3db32c04' 
  AND token = 'ME8RV9N4qx4IX+QUw/K5y3m7wxR27uZwPg4tydPQ+68=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}