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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed3151dcd824f0bb6d0a3956da63c5ddac46d77c1d997d31413f48e839dd3ba3' 
  AND token = '+1+EHpNjxuYbaIXHSwFI0ibUmpPStkeF3ygJrVxJd/8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}