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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d89b389729a9e6a6901386404a81a5cda7d0424d0660b0af14d43601ec0c4cc' 
  AND token = 'k29u21dxI7UQcfx0OSbvmmr03FA3nsHfMZFwbuV5ZAs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}