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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3178e49f4be6547a00ffedd43571f2ff2521cdb30e5a2ca7c5d441d408741acb' 
  AND token = '44gISCQYj5A5kNqN5xlWNpJFh8tmH0xKXgOQUK2QjTM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}