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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6a3a729d143246f7ab91bda501e00a2c060846b682b6ce85a72f674e939790c7' 
  AND token = 'AQ7bK+EtXWZ2lpbzPynLL+kZHuPM3JOe0WDg20Ft5UA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00064

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}