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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de785467f0d812e16d65d4aa819ba293eb689cf42914e0f8dbeb3b9a779d84b4' 
  AND token = 'P9NXlUugabF0WfhFEM3qZjdEXb22uuGvLnHGDF32dPY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}