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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4c3d1ba48177ad3061825d4f219c52234844249f6dfbbd7fff5c8af0e4936a22' 
  AND token = 'N0BVa5TtCgtjM8LFsmVcjak7+5ElOdwrHKQXiRN18QA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}