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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16680b078dbaa506d812b7d1c46e033ec6612568494fbb6771336fcf309e3b46' 
  AND token = 'QY6N2Jo4WTQsOxIHb3NSd6L1e0gS2AQ84txbI5DC3Ck=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}