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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22d3a163e06bc09368d13568de14648b4b5235d3ea27fd54d6733d43ee0021d4' 
  AND token = 'GXG+M2m7rqbIgtNDWFOGRVkwSFpr9HW4p5zKzGvUm8o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}