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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9da4c725acc0a372b69a9653609092d0d0f5d604b9ce9a5da48cde50e3160820' 
  AND token = '4HWIL1VrbErLyeSDE1cYrr5SReHPaLV6UAHCDe/0ibk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}