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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c5dfe7782cf4cf7f087fa5d46813e500727f247cdfe66812e4636d7f989fa588' 
  AND token = 'iTx3qxNhO68PFSqUE5DhXUH60sWEi/GXY9Ou4ftEAdA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}