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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9ee663a08e56e16b64bb5e35384e81a984f89a51302f170233c1d1e517df16d5' 
  AND token = 'PlKBzG8A9fdeoPNxQpTu/zGp4t3DNCZt2Dx4uyUFKqY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}