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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4206f644e2a0dc39f08e2d7bb79a387151655c432abaafe75a23da467fbec5a0' 
  AND token = 'kH43RK8Pks+k96JTMft6qIf6G0PAyzkGkljaD0WqF9o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}