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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3455ec59e3a11a828d7a4bc892e2b068fe5168de9c5a3663fe4232c5deb8e1f4' 
  AND token = 'hw7Ata4FrtPwmVkO9n+X7AK+uZumkGRnFXgqZv5u54M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}