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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ef5b9f51329a6fa91f050d3a2f61d715fd21f08d7b67e55a072459a41e496b1a' 
  AND token = 'HTPbS0G27QlMZLeUp8PwX9fxsg+1RLAl1skZVOpzPA0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}