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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8c879ab7537dd5eb2f492c2268d15ead07343d1674fd8ded8c5e75ce331b65c8' 
  AND token = '/TBzkDdrpPpg1g02L6cP8b/8eQFaODD/yOBp/cUH2Ow=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}