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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a18e44778a888388ee8ab247c6ba3dfd0a440d1306909409c884f2f904f5a11e' 
  AND token = 'TX+c87zgKuI4HKpXfA9wplPhpHohBIBz2cPEGtO7Cfo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}