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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd21a886a9e2dc9b8a426c4ba56bb9d3da8519c485820bc5f87ab999c656a6a6f' 
  AND token = 'PJRUAMhKw7gFTsT3Tss+fAhh/47QMa9hBUvlEkqUEkA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}