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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '301dd017339344bac73741735dd89552ff3e433b0133c29d8ca20b8d6d0a6d4d' 
  AND token = '6UCDwPeqecwbmx7FLKK1lsr/xyHRx0NmTVwfTl4gdsc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}