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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45b720fd14cb0d71e18ebf926f8e436ed963e06dd0a5364dd98339edfe953542' 
  AND token = 'yQxAeAl5vJ9y7xmOy3a1mzFwV//+mAoBmkhqw9gMa6k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}