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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42603db6741510514e9f8e82e93f0f0a50b1d860e8b5665126c358056ce5869b' 
  AND token = 'E5nUvHeTWqQootq7b+Y57BGA1BogY6npVhuKddw2Z0I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}