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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6a4f0cb94d53a2951bab3e8166d2541e4298bbd34f22317663bc22be0f75f852' 
  AND token = 'ap0cafXvzM4DbEmmbKE2aEm3uYgYqM2TBepV473Qong=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}