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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65105681d782267ee082b4b06c1daa663048db3b7bf3a0c656128c9657efe1c8' 
  AND token = 'NSeOJhDkudg7KHzyFDXGojuFI8S9XZzmdStPDdlXmHI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}