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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1a77c17daee47be0b0adbe9d7c73d38502dfb089ba74184cf0587f48cad3f408' 
  AND token = '+RuLusw22XtFrnLRPwB1aw+wbeu2TK9VI4HYpnJvfVM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}