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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16271463fd01c107e24bc21ccde23f513975338b83bf6fcca4f25af3245b7f3b' 
  AND token = 'hW9WiXNUYdAC0HZ8Hk+BA33DFPA4a2iK50xoJrHWirY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}