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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '195bbcc030179e96b11233aa650959f9dd2a845d621cb2f484fad4ee2c1d8f9e' 
  AND token = '7cOA1MQDpkeYtI4uiYC15S1K0siUqeM/91EL71NhCsM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}