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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b2bd830a6d21205c7e6074948983907644c28fb1900920066e29d72f7717ee6' 
  AND token = 'Kley0/TAmsV5KgOb+mAT0XtiFoR8fMlhxldNmmmkcdY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}