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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e66ebd2ce2c7014f3de90aeaa4a59b15e8998d08396d203a7899094aa5e85c4' 
  AND token = 'ApfN/PtmZDDHfy90bJqRJ9moIpnoI9Xx2uEvhi6RGUM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}