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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21da3c022eaffd56e8957d9c6942bfb66d556bd68af2fef8fd0ad5ae2dc889d2' 
  AND token = 'a+Ur5HfkHDvg4R9rraM9O6EX21r0x7zKWodX2Ikdy+Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}