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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '216be208f746f7f074ee3fb77f22756c938e6bfd7a5ea8b3f26f2af61735efe5' 
  AND token = 'jlHX+h/SbeRmwp4WvkGfjE8HBIp0qe7GXDYM0vv4qQ8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}